Reference valuesReference values

Obstetric — 2nd/3rd trimester — Reference values

Obstetric — 2nd/3rd trimester — Reference values: Amniotic fluid index (AFI), Biometry (BPD, HC, AC, FL), Calculator — amniotic fluid (AFI / deepest pocket).

Measurements and reference values

MeasurementUsual valueNote
Amniotic fluid index (AFI)5–25 cmsingle deepest pocket normal: 2–8 cmSource: Ultrasoundpaedia / FMF
Biometry (BPD, HC, AC, FL)use gestational-age tables (Hadlock/FMF) — no single valueSource: Hadlock / FMF

Classifications and calculators

Calculator — amniotic fluid (AFI / deepest pocket)

RangeAFIDeepest pocket
Oligohydramnios≤ 5 cm< 2 cm
Normal8–18 cm (5–24)2–8 cm
Polyhydramnios≥ 24 cm≥ 8 cm

SMFM prefers the single deepest pocket (fewer false-positive oligohydramnios). Correlate with gestational age, growth and membrane integrity.

Source: Phelan/Moore (AFI) / SMFM / ISUOG

Calculator — fetal Doppler (umbilical/MCA/CPR)

FindingReading
Normal umbilical, normal MCARoutine surveillance.
Umbilical PI >95th or MCA <5th or CPR <5thRedistribution/resistance: increase surveillance.
Absent umbilical diastole (AEDF)Advanced placental insufficiency.
Reversed umbilical diastole (REDF)Severe: fetal medicine; ductus venosus/delivery per GA.

Indices are gestational-age specific (FMF references). Absent/reversed umbilical diastole is the most severe sign.

Source: ISUOG Doppler guidelines / Delphi FGR consensus 2016

Placenta previa and accreta spectrum (PAS)

SituationDefinition/signManagement
Normally sited placentaEdge ≥2 cm from internal os.No restriction by location.
Low-lying placentaEdge <2 cm from os, not covering.Reassess in the 3rd trimester.
Placenta previaCovers the internal os.Cesarean; plan delivery.
Accreta spectrum (PAS)Lacunae, loss of clear zone, hypervascularity, bulging (prior cesarean + previa).Referral center; multidisciplinary team.

Accreta risk rises sharply with previa over a cesarean scar. Document edge-to-os distance and invasion signs.

Source: FIGO PAS 2019 / ISUOG placenta previa & PAS guideline

Cervical length (preterm birth)

Cervix (transvaginal)Reading
≥ 25 mmLow preterm birth risk.
15–24 mmShortened: consider progesterone/follow-up.
< 15 mm or funnelingHigh risk: refer; discuss cerclage/pessary.

Measure transvaginally, empty bladder, no excess pressure; use the shortest of 3. 25 mm cutoff in the 2nd trimester.

Source: FMF / SMFM / ISUOG cervical assessment

Fetal Doppler — alert thresholds

Vessel/indexAbnormalMeaning
Umbilical artery — PI> 95th centileincreased placental resistance
Middle cerebral artery — PI< 5th centileredistribution (brain-sparing)
Cerebroplacental ratio (CPR)< 10th centileearly placental insufficiency

Indices are gestational-age specific (FMF references). Absent/reversed umbilical end-diastole = severe.

Source: FMF (Ciobanu 2019, UOG)

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